MLB Picks · September 25, 2026

Chicago Cubs vs Boston Red Sox

Lean
Chicago Cubs ML
-115
69
/ 100
Starting Pitchers
Chicago Cubs · Away
Clay Holmes (RHP)
Boston Red Sox · Home
Alec Gamboa (LHP)
AI Analysis

Clay Holmes (ERA 3.25, WHIP 1.16) has been one of the more reliable starters of the second half and gives Chicago a clear pitching edge over Gamboa, who has only 31 IP at the MLB level. The Cubs lineup hits significantly better vs LHP (.262/.796 vs .247/.759 vs RHP), giving them a real split advantage against Gamboa. Boston's offense has been ice cold — just 2.2 R/G over their last 10 games — and their top hitters (Contreras, Abreu, Monasterio) are all flashing cold signs recently. The Cubs are small road favorites at -115 and represent fair value given the pitching gap.

Concerns
  • •Gamboa's tiny MLB sample (31 IP) makes ERA 1.16 hard to trust but also hard to fade completely
  • •Cubs offense also sluggish in L5 — 4.5 R/G on L10 but AVG .243
  • •Fenway Park historically suppresses visitor run totals
Factor Breakdown
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