MLB Picks · September 24, 2026

St. Louis Cardinals vs Pittsburgh Pirates

Lean
Pirates ML
-164
66
/ 100
Starting Pitchers
St. Louis Cardinals · Away
Kyle Leahy (RHP)
Pittsburgh Pirates · Home
Paul Skenes (RHP)
AI Analysis

Paul Skenes is the clear pitching edge here — his 1.13 WHIP and 192 strikeouts in 168 IP vastly outperform Leahy's 1.34 WHIP at a lighter workload. The Cardinals offense is in a severe cold stretch (OPS .566, AVG .205 over L5 with 3.4 R/G), and most of their top hitters are cold ❄️. Pittsburgh's offense hits RHP well (.256/.752) and has multiple hot hitters including Brandon Lowe (🔥 .346 L14) and Oneil Cruz (🔥 .340 L14). Home field adds further support at PNC Park. The Skenes advantage is meaningful but his 3.91 ERA and 10-11 record temper enthusiasm slightly, keeping this a lean rather than a strong lean.

Concerns
  • •Skenes ERA (3.91) and W-L (10-11) are underwhelming for a true ace
  • •STL has Jose Fermin and Nathan Church running hot recently
  • •Pirates offense (.260 L5 AVG) has scored only 4 R/G in last 10 games
  • •Skenes faces a lineup he's seen repeatedly — familiarity risk
Factor Breakdown
Powered by AI scoring across 6 proprietary factors. For informational and entertainment purposes only — not financial or betting advice, and results are not guaranteed. Must be 21+ or the applicable minimum age in your jurisdiction to wager.
Gambling problem? Call 1-800-GAMBLER. · More resources on the About page.